From the Research
Yes, modafinil tablets can be split, and according to the most recent and highest quality study, there is little evidence to support concerns regarding tablet splitting, except for sustained-release tablets which should not be split 1. When splitting modafinil, it is recommended to use a pill cutter for the most accurate division, as breaking by hand can result in uneven pieces. The ability to split modafinil can be helpful for those who are just starting the medication and need to titrate their dose, or for those who experience side effects at higher doses and need to reduce their intake. Some key points to consider when splitting modafinil include:
- The medication may have a bitter taste and could produce some powder
- It is essential to consult with a healthcare provider before adjusting the dose, as they can provide guidance specific to individual medical needs
- The recommended dosage of modafinil is 200 or 400 mg/day, given once or twice daily (morning and midday) to patients with narcolepsy 2
- Modafinil has been shown to be effective in reducing excessive daytime sleepiness and improving wakefulness in patients with narcolepsy, with a good safety profile and low risk of abuse 2, 3