Is there an association between extended Apixaban (apixaban) use and the incidence of cerebral thromboembolic events in cats?

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From the FDA Drug Label

The FDA drug label does not answer the question.

From the Research

Extended use of apixaban does not have any known association with increased incidence of cats. Apixaban (brand name Eliquis) is an anticoagulant medication that belongs to the class of direct oral anticoagulants (DOACs) and is used to prevent blood clots in conditions like atrial fibrillation and deep vein thrombosis. The medication works by inhibiting Factor Xa, which is involved in the blood clotting process. The standard dosing for apixaban is typically 5mg twice daily for most patients, with a reduced dose of 2.5mg twice daily for certain populations including those with renal impairment, low body weight, or advanced age. Extended use of apixaban is common for chronic conditions requiring ongoing anticoagulation, and its safety profile has been well-established in long-term use, as shown in a study published in 2025 1. Side effects may include increased risk of bleeding, but there is no medical or scientific connection between apixaban use and cats, either in terms of pet ownership, allergies to cats, or any other feline-related concerns. If you're experiencing unusual symptoms while taking apixaban, you should consult with your healthcare provider. Some key points to consider when using apixaban include:

  • The medication is effective in preventing recurrent venous thromboembolism in patients with active cancer, as demonstrated in a study published in 2025 1.
  • Extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for the prevention of recurrent venous thromboembolism in patients with active cancer, and led to a lower incidence of clinically relevant bleeding complications than the full dose 1.
  • Apixaban use was associated with decreased risks of recurrent VTE and mortality, without increased major bleeding risk, compared to no extended treatment or warfarin, as shown in a study published in 2023 2. It's essential to follow the recommended dosage and consult with your healthcare provider if you have any concerns or questions about apixaban use.

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