Why is hydroxyzine used for pityriasis rosea?

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Last updated: February 19, 2025View editorial policy

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From the Guidelines

Hydroxyzine is used to treat pityriasis rosea due to its antihistamine and anti-pruritic properties, which can help alleviate itching and discomfort associated with the condition 1.

Key Points

  • The typical dose of hydroxyzine for pruritus is 25-50 mg daily 1, however the exact dosing for pityriasis rosea may vary.
  • Hydroxyzine is a first-generation antihistamine, which may be considered for use in patients who suffer from pruritus during night time due to its sedative properties 1.
  • It's essential to note that hydroxyzine is not a first-line treatment for pityriasis rosea, and its use should be considered on a case-by-case basis, taking into account the individual's symptoms and medical history.
  • As with any medication, it's crucial to consult a healthcare professional before starting treatment with hydroxyzine. Some potential benefits of using hydroxyzine for pityriasis rosea include:
  • Relief from itching and discomfort
  • Improvement in sleep quality due to its sedative properties However, it's essential to weigh these benefits against the potential risks and side effects of hydroxyzine, and to carefully consider alternative treatment options.

From the Research

Pityriasis Rosea Treatment

  • Pityriasis rosea is a common, acute, self-limiting exanthematous skin disease that primarily affects children and young adults 2.
  • The treatment options for pityriasis rosea include acyclovir, macrolides, and ultraviolet phototherapy 2.
  • Antihistamines, such as hydroxyzine, can be used to control symptoms like itchiness 3, 4.
  • Hydroxyzine is used for its antihistamine and antipruritic properties to relieve itching and reduce the discomfort associated with pityriasis rosea 3, 4.

Hydroxyzine Usage

  • Hydroxyzine can be used to treat pruritic skin lesions, but it can sometimes worsen dermatitis in patients with sensitivities to phenothiazines and/or ethylenediamines 5.
  • The use of hydroxyzine should be carefully considered, especially in patients with a history of allergies or sensitivities 5.
  • In the context of pityriasis rosea, hydroxyzine may be prescribed to alleviate itching and improve the patient's quality of life 3, 4.

Alternative Treatments

  • Acyclovir has been shown to be effective in reducing the duration of pityriasis rosea and improving symptoms 2, 3.
  • L-lysine therapy has also been reported to control the clinical evolution of pityriasis rosea, although more research is needed to confirm its effectiveness 6.
  • Corticosteroids and ultraviolet phototherapy are other treatment options available for pityriasis rosea, especially in severe cases 2, 4.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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