From the Research
An elevated TSI level indicates the presence of Graves' disease, and the recommended treatment is anti-thyroid medications, with methimazole being the preferred choice due to its efficacy and safety profile, as shown in a recent meta-analysis 1. The treatment approach for Graves' disease typically involves:
- Anti-thyroid medications, such as methimazole (starting at 10-30mg daily) or propylthiouracil (100-300mg daily in divided doses), which block thyroid hormone production
- Beta-blockers, such as propranolol (20-40mg every 6-8 hours), to manage symptoms like rapid heartbeat and tremors
- Regular monitoring of thyroid function tests every 4-6 weeks initially Alternative treatments, such as radioactive iodine therapy or thyroidectomy, may be considered if medication fails or isn't tolerated. It's essential to note that the clinical diagnostic performance of the TSI assay is comparable to that of the thyroid-stimulating hormone receptor antibody assay, making it a valuable tool for diagnosing Graves' disease 2. The initial FT4 and TSI levels can be used as predictors of the responsiveness to methimazole in patients with newly diagnosed Graves' disease 2. Untreated hyperthyroidism can lead to severe consequences, including cardiac arrhythmias, heart failure, osteoporosis, and adverse pregnancy outcomes, emphasizing the importance of prompt treatment and regular monitoring 3.