From the Research
The normal reference range for DHEA (dehydroepiandrosterone) varies by age and sex, with adult men typically ranging from 1.8 to 12.5 ng/mL and adult women ranging from 1.3 to 9.8 ng/mL, as supported by the most recent study 1.
DHEA Reference Range
The reference range for DHEA is influenced by various factors including age, sex, and the laboratory conducting the test.
- For adult men, DHEA levels typically range from 1.8 to 12.5 ng/mL.
- For adult women, the range is usually 1.3 to 9.8 ng/mL. These values decrease naturally with age, with peak levels occurring in early adulthood (around age 20-30) and declining by approximately 10% per decade thereafter.
DHEA-Sulfate (DHEA-S) Reference Range
For DHEA-sulfate (DHEA-S), which is the more commonly measured form, reference ranges are higher:
- Approximately 80-560 μg/dL for adult men.
- Approximately 35-430 μg/dL for adult women.
Interpreting DHEA Levels
When interpreting DHEA levels, it's essential to consider the patient's age, as what might be low for a young adult could be normal for someone older.
- Abnormal DHEA levels may indicate adrenal disorders, certain cancers, or other hormonal imbalances.
- Testing should be done in the morning when levels are highest, and results should always be interpreted within the clinical context by a healthcare provider, as suggested by 2.
Clinical Considerations
The use of DHEA as a replacement therapy has been proposed, particularly in older adults and postmenopausal women, as it may have beneficial effects on bone mineral density, sexual function, and overall well-being, as reported in studies such as 3 and 4. However, more research is needed to fully understand its effects and potential benefits.
- The most recent and highest quality study 1 provides evidence on the effects of DHEA supplementation on estradiol levels in women, which is essential for guiding clinical decisions.