From the FDA Drug Label
Clindamycin is also indicated in the treatment of serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci Infections of the female pelvis and genital tract such as endometritis, nongonococcal tubo-ovarian abscess, pelvic cellulitis, and postsurgical vaginal cuff infection. Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to clindamycin The antibiotic that may be used for female UTI with Staphylococcus pseudintermedius is clindamycin (PO), but only if the strain is susceptible to clindamycin, as determined by bacteriologic studies 1.
From the Research
For a female urinary tract infection (UTI) caused by Staphylococcus pseudintermedius, the most appropriate antibiotic option is trimethoprim-sulfamethoxazole (Bactrim) or nitrofurantoin, as these have been shown to be effective against a wide range of uropathogens, including those with variable resistance patterns, as noted in 2. When considering treatment options, it's essential to take into account the potential for antibiotic resistance, as highlighted in 3, which emphasizes the importance of judicious use of antibiotics through antimicrobial stewardship principles. The choice of antibiotic should ideally be guided by susceptibility testing, as S. pseudintermedius can have variable resistance patterns, making it crucial to select an effective treatment, as mentioned in 2. A typical regimen for uncomplicated UTI would be trimethoprim-sulfamethoxazole DS (double strength) twice daily for 3-5 days, or nitrofurantoin 100mg twice daily for 5-7 days, as outlined in 2. Patients should complete the full course of antibiotics even if symptoms improve quickly, drink plenty of fluids during treatment, and follow up if symptoms don't improve within 48-72 hours, as advised in 4. Those with recurrent infections, fever, flank pain, or other concerning symptoms should seek immediate medical attention, as these may indicate a more serious infection requiring different management, as noted in 5. It's also important to note that S. pseudintermedius is more commonly associated with infections in dogs and cats, so its presence in a human UTI is unusual and may warrant further investigation, as reported in 6.