Breztri Prescription Sig and EMR Quantity for 90-Day Supply
For a 90-day supply of Breztri, write the sig as "Inhale 2 puffs by mouth twice daily (morning and evening)" and enter a quantity of 3 inhalers in your EMR.
Dosing Details
The FDA-approved dosing for Breztri Aerosphere is 2 inhalations twice daily (morning and evening), which delivers budesonide 320 mcg, glycopyrrolate 18 mcg, and formoterol fumarate 9.6 mcg per dose 1. This means:
- Daily usage: 4 inhalations per day (2 puffs × 2 times daily)
- Monthly usage: approximately 120 inhalations (4 × 30 days)
- 90-day usage: approximately 360 inhalations (4 × 90 days)
Quantity Calculation
Each Breztri Aerosphere inhaler contains 120 metered inhalations 1. For a 90-day supply:
- 360 total inhalations needed ÷ 120 inhalations per inhaler = 3 inhalers
Enter "3" as the quantity in your EMR when prescribing for 90 days.
Important Prescribing Instructions
Include these key points in your prescription or patient counseling:
- Do not exceed 2 inhalations twice daily 1
- Rinse mouth with water without swallowing after each use to reduce risk of oral candidiasis 1
- Prime the inhaler before first use (4 sprays) and re-prime if not used for >7 days (2 sprays) 1
- Discard when dose counter reaches zero (red zone) 1
Common Pitfall
Do not confuse the number of inhalers (3) with the number of inhalations per dose (2). The EMR quantity field should reflect the number of physical inhaler devices dispensed, not the number of puffs.