What is the treatment for pleurisy?

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Last updated: May 12, 2025View editorial policy

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From the Guidelines

Pleurisy treatment should prioritize addressing the underlying cause and managing symptoms, with a focus on reducing inflammation and preventing complications, as recommended by the most recent guidelines 1.

Treatment Approach

The treatment approach for pleurisy depends on the underlying cause, which can include bacterial infections, viral infections, autoimmune conditions, or pneumothorax.

  • Bacterial infections require antibiotics, with the choice of antibiotic guided by bacterial culture results or covering community-acquired bacterial pathogens and anaerobic organisms 1.
  • Viral infections generally resolve with supportive care.
  • Autoimmune conditions may need immunosuppressants.
  • Pneumothorax might require chest tube placement.

Pain Management

For pain relief, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (400-800mg every 6-8 hours) or naproxen (500mg twice daily) are typically recommended.

  • If pain is severe, stronger pain medications or corticosteroids may be prescribed to reduce inflammation.
  • Applying heat to the painful area can provide additional comfort.

Surgical Intervention

Surgical intervention may be required for patients with pleural infection who fail to improve with optimal medical therapy, with the choice of surgical approach depending on the individual patient's needs 1.

  • The use of small bore chest tubes (14F or smaller) is recommended for initial drainage of pleural infection 1.
  • Different surgical methods can be deployed, including drainage, debridement, and visceral decortication.

Recovery and Prevention of Complications

While recovering, rest is important, and breathing exercises can help prevent complications.

  • Most cases improve within a few days to weeks with appropriate treatment.
  • If breathing becomes difficult or pain worsens despite treatment, immediate medical attention is necessary as this could indicate a worsening condition.

From the Research

Pleurisy Treatment Overview

  • Pleurisy treatment typically consists of pain management with nonsteroidal anti-inflammatory drugs, as well as specific treatments targeted at the underlying cause 2
  • The diagnosis of pleurisy can be made after excluding other significant causes of pleuritic pain, such as pulmonary embolism, pericarditis, pneumonia, myocardial infarction, and pneumothorax 2

Diagnostic Approach

  • History, physical examination, and chest radiography are recommended for all patients with pleuritic chest pain 2
  • Electrocardiography is helpful, especially if there is clinical suspicion of myocardial infarction, pulmonary embolism, or pericarditis 2
  • Thoracocentesis should be performed for new and unexplained pleural effusions to determine the etiology of the effusion 3

Management of Pleural Effusion

  • Transudative effusions are usually managed by treating the underlying medical disorder 3
  • Exudative effusions require management based on the underlying etiology of the effusion 3
  • Malignant effusions are usually drained to palliate symptoms and may require pleurodesis to prevent recurrence 3, 4
  • Empyemas need to be treated with appropriate antibiotics and intercostal drainage 3

Treatment Options

  • Pleurodesis, thoracoscopy, and video-assisted thoracoscopy are treatment options for pleural effusion 4
  • The placement of a permanently indwelling pleural catheter is also a treatment option 4
  • The proper treatment of pleural effusion can be determined only after meticulous differential diagnosis 4

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Pleurisy.

American family physician, 2007

Research

Pleural effusion: diagnosis, treatment, and management.

Open access emergency medicine : OAEM, 2012

Research

Pleural Effusion in Adults-Etiology, Diagnosis, and Treatment.

Deutsches Arzteblatt international, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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