From the Guidelines
For individuals with Classical Ehlers-Danlos Syndrome (EDS), EDS, or Joint Hypermobility Syndromes, the most effective anti-aging treatment to improve skin quality is the use of autologous platelet concentrates, such as platelet-rich fibrin (PRF), which has been deemed extremely effective in minimizing further facial aging and potentially reversing it. This approach is supported by a recent study published in 2025 1, which highlights the importance of addressing the underlying causes of facial aging, including deep fat atrophy and vascular degeneration.
The signs of aging in individuals with EDS or Joint Hypermobility Syndromes can be particularly pronounced due to impaired regeneration capacity and natural barrier function of the skin. Key areas of concern include:
- Periorbital and perioral regions, which are more frequently clinically related to visible signs of aging
- Deep fat atrophy, primarily caused by a decrease in age-related blood flow
- Vascular degeneration, considered a major cause of the initiation of facial aging
Given the fragile skin associated with EDS conditions, it is essential to prioritize gentle, non-invasive approaches. Some additional considerations include:
- Topical retinoids at low concentrations (0.025-0.05%) to support collagen production
- Vitamin C serums (10-15% L-ascorbic acid) for antioxidant protection and collagen support
- Hyaluronic acid moisturizers to hydrate the skin without causing excessive stretching
- Sun protection with broad-spectrum SPF 30+ daily
- Peptide-based products as gentler alternatives to more aggressive treatments
However, autologous platelet concentrates, such as PRF, offer a more targeted approach to addressing the underlying causes of facial aging, making it a preferred treatment option for individuals with Classical EDS, EDS, or Joint Hypermobility Syndromes 1. As always, consultation with a dermatologist familiar with connective tissue disorders is crucial to determine the best course of treatment.
From the Research
Anti-Aging Treatments for Classical EDS, EDS, or Joint Hyper mobility syndromes
There are no specific studies that directly address anti-aging treatments for improving skin quality in individuals with Classical EDS, EDS, or Joint Hyper mobility syndromes. However, the following information can be gathered from the available studies:
- The skin is one of the most commonly affected body parts in heritable connective tissue disorders, such as Ehlers-Danlos Syndrome (EDS) 2.
- EDS is characterized by joint hypermobility, skin hyperextensibility, and tissue fragility 3.
- The hypermobile type of EDS (hEDS) involves generalized joint hypermobility, musculoskeletal manifestations, and mild skin involvement along with the presence of several comorbid conditions 3.
- Management principles for EDS and joint hypermobility syndrome include a multidisciplinary approach, covering pharmacologic, physical and occupational therapy, surgical, and nutriceutical aspects, as well as general lifestyle recommendations 2.
- There is no specific mention of anti-aging treatments in the provided studies, but it can be inferred that a comprehensive management plan may include measures to improve skin quality and reduce the risk of skin-related complications.
Key Considerations
- Individuals with EDS or joint hypermobility syndrome may require specialized care and management to address their unique needs and symptoms 2, 4, 5, 3, 6.
- A thorough assessment and diagnosis are crucial to develop an effective treatment plan 2, 4, 5, 3, 6.
- Further research is needed to understand the complex phenotypes and genetic basis of EDS and joint hypermobility syndrome, which may lead to the development of targeted treatments and therapies 3.