I received a letter from Express CRPIT titled "Patient Safety and Health Consideration"; what does this mean?

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Last updated: May 14, 2026 • View editorial policy

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Understanding Your Express Scripts Patient Safety Letter

The letter you received from Express Scripts regarding "Patient Safety and Health Consideration" is most likely a notification about a medication safety concern, drug recall, formulary change, or important prescribing information update that affects a medication you or your patient is currently taking.

What This Letter Typically Means

Express Scripts (not "CRPIT") is a pharmacy benefit management company that sends these letters when:

  • A medication safety alert has been issued by the FDA or manufacturer
  • A drug recall or withdrawal has occurred
  • New safety information has emerged about a medication's risks or side effects
  • Formulary changes are being implemented that affect medication coverage
  • Prior authorization requirements have changed for a specific medication
  • Therapeutic alternatives are being recommended due to safety or cost considerations

Immediate Actions You Should Take

Read the letter carefully and identify which specific medication is being referenced. The letter should clearly state:

  • The medication name (brand and generic)
  • The specific safety concern or change
  • What action is required (if any)
  • Contact information for questions

Contact Express Scripts directly using the phone number or reference number provided in the letter if:

  • The letter is unclear about which medication is affected
  • You need clarification on recommended actions
  • You need to discuss alternative medications

Consult with your prescribing physician or pharmacist to:

  • Review whether you should continue the medication
  • Discuss alternative treatment options if discontinuation is recommended
  • Adjust dosing if new safety parameters have been established
  • Schedule monitoring if new surveillance requirements exist

Common Pitfalls to Avoid

  • Do not ignore the letter - these communications are sent for legitimate patient safety reasons 1
  • Do not stop medications abruptly without medical guidance, as this can be dangerous
  • Do not assume the letter is spam - Express Scripts is a legitimate pharmacy benefit manager
  • Do not delay action if the letter indicates urgent safety concerns

Context About Patient Safety Communications

Healthcare systems increasingly use systematic reporting and communication systems to notify patients and providers about safety incidents, medication errors, and emerging safety data 1. These letters represent an important component of patient safety infrastructure designed to reduce preventable harm 2.

If you cannot locate the letter or need immediate clarification, call Express Scripts member services directly at the number on your insurance card.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.