What is the cause of right second toe pain?

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Last updated: May 13, 2025View editorial policy

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Differential Diagnosis for Right Middle Toe Pain

  • Single most likely diagnosis
    • Morton's neuroma: This condition is a common cause of toe pain, especially in the middle toes, due to compression or irritation of the nerve between the toes.
  • Other Likely diagnoses
    • Ingrown toenail: This condition can cause pain and discomfort in the toe, especially if the nail is pressing into the surrounding skin.
    • Hammertoe: A deformity of the toe that can cause pain and discomfort, especially if the toe is rubbing against the shoe.
    • Gout: A form of arthritis that can cause sudden, severe pain in the toes, especially the big toe, but can also affect other toes.
    • Bursitis: Inflammation of the fluid-filled sacs that cushion the joints, which can cause pain and swelling in the toe.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Osteomyelitis: A bone infection that can cause severe pain and swelling in the toe, and can lead to serious complications if left untreated.
    • Deep vein thrombosis (DVT): A blood clot in the deep veins of the leg that can cause pain and swelling in the toe, and can lead to a pulmonary embolism if the clot breaks loose.
    • Diabetic neuropathy: Nerve damage caused by diabetes that can cause pain, numbness, and tingling in the toes.
  • Rare diagnoses
    • Toe fracture: A break in one of the bones in the toe, which can cause pain and swelling.
    • Psoriatic arthritis: A form of arthritis that can cause pain and swelling in the toes, especially in people with psoriasis.
    • Rheumatoid arthritis: A form of arthritis that can cause pain and swelling in the toes, especially in people with a history of the disease.
    • Ganglion cyst: A non-cancerous lump that can form on the toe, causing pain and discomfort.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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