What is the diagnosis and treatment for Peyronie's disease?

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Last updated: February 19, 2025View editorial policy

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Differential Diagnosis for Bent Penis

  • Single most likely diagnosis
    • Peyronie's disease: This condition is characterized by the formation of fibrous scar tissue inside the penis, leading to curved, painful erections. It is the most common cause of a bent penis and typically presents in middle-aged men.
  • Other Likely diagnoses
    • Penile fracture: A penile fracture occurs when the penis is bent or twisted, causing a tear in the tunica albuginea, the fibrous layer surrounding the corpora cavernosa. This condition often results from traumatic injury during sexual activity.
    • Congenital penile curvature: Some men are born with a curved penis due to abnormal development during fetal growth. This condition may become more apparent during puberty.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Penile cancer: Although rare, penile cancer can cause a bent or deformed penis. Early detection and treatment are crucial to prevent metastasis and improve prognosis.
    • Urethral stricture: A urethral stricture can cause a bent or curved penis due to scarring and narrowing of the urethra. If left untreated, it can lead to urinary retention, kidney damage, and other complications.
  • Rare diagnoses
    • Klinefelter syndrome: This genetic disorder can cause a variety of physical and hormonal abnormalities, including a bent or small penis.
    • Epispadias: A rare congenital condition where the urethra opens on the top of the penis, often associated with a curved or bent penis.
    • Fibrosis due to injection or trauma: In rare cases, injection of substances into the penis or traumatic injury can cause fibrosis and scarring, leading to a bent penis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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