What is the cause of bilateral hand pain?

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Last updated: May 13, 2025View editorial policy

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Differential Diagnosis for Bilateral Hand Pain

  • Single most likely diagnosis
    • Osteoarthritis: This is a common condition that affects the joints, leading to pain and stiffness, especially in older adults. Bilateral hand pain could be due to osteoarthritis affecting the joints in both hands.
  • Other Likely diagnoses
    • Rheumatoid Arthritis: An autoimmune disorder that causes inflammation and pain in the joints, often affecting the hands bilaterally.
    • Carpal Tunnel Syndrome: A condition that occurs when the median nerve is compressed, leading to pain, numbness, and tingling in the hands, which can be bilateral.
    • Tendinitis: Inflammation of the tendons in the hands can cause bilateral pain, especially with repetitive activities.
    • Ganglion Cysts: Non-cancerous lumps that can develop on the joints or tendons of the hands, causing pain and discomfort.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Septic Arthritis: A bacterial infection in the joint that can cause severe pain, swelling, and potentially lead to serious complications if not treated promptly.
    • Complex Regional Pain Syndrome (CRPS): A chronic pain condition that can occur after an injury, causing severe pain, swelling, and changes in skin temperature and color.
    • Vasculitis: Inflammation of the blood vessels that can cause pain, numbness, and tingling in the hands, and can be a sign of a more serious underlying condition.
  • Rare diagnoses
    • Scleroderma: A rare autoimmune disorder that can cause thickening and hardening of the skin, leading to pain and limited mobility in the hands.
    • Erythromelalgia: A rare disorder that causes burning pain, heat, and redness in the hands and feet.
    • Raynaud's Phenomenon: A condition that affects blood flow to the fingers and toes, causing pain, numbness, and discoloration in response to cold temperatures or stress.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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