How to use Imvexxy (estradiol vaginal insert)?

From the Guidelines

Imvexxy should be used as a vaginal estrogen therapy to treat vaginal dryness and pain during intercourse caused by menopause, with a recommended dosing of one insert daily for two weeks, then twice weekly maintenance, as supported by recent guidelines 1. To use Imvexxy, first wash your hands thoroughly. Remove the vaginal insert from its packaging and place it in your vagina using your finger, inserting it as far as comfortable.

Key Considerations

• The recommended dosing is one insert daily for two weeks, then twice weekly maintenance (typically every 3-4 days) 1.
• Imvexxy comes in two strengths: 4 mcg and 10 mcg, with your doctor prescribing the appropriate dose for your needs.
• Use Imvexxy at the same time each day for best results.
• You can insert it while lying down, squatting, or standing with one leg raised.
• The insert dissolves in the vagina, so you don't need to remove anything afterward.
• Avoid using other vaginal products for at least 2 hours after insertion.
• If you miss a dose, use it as soon as you remember unless it's almost time for your next dose. Imvexxy works by delivering estrogen directly to vaginal tissues, helping to restore thickness, elasticity, and natural lubrication with minimal systemic absorption compared to oral hormone therapies, as noted in the NCCN guidelines 1.

Important Safety Information

• Vaginal estrogen is the most effective treatment for vaginal dryness leading to sexual dysfunction and has been shown to be effective in treating itching, discomfort, and painful intercourse in postmenopausal individuals 1.
• A large cohort study of almost 50,000 patients with breast cancer followed for up to 20 years showed no evidence that there was a higher risk of breast cancer–specific mortality in those using vaginal estrogen 1.

From the Research

Imvexxy Usage

To use Imvexxy, which is an estradiol vaginal insert, it is essential to follow the prescribed instructions and guidelines provided by a healthcare professional.

• The insert is typically used to treat moderate to severe dyspareunia (painful sex) due to menopause.
• It is inserted into the vagina with an applicator, usually once a week.
• Before using Imvexxy, it is crucial to inform your healthcare provider about any medical conditions, such as a history of blood clots, stroke, or cancer, as well as any medications you are currently taking 2, 3, 4, 5, 6.
• Regular check-ups with your healthcare provider are necessary to monitor the effects of Imvexxy and adjust the treatment plan as needed.

Potential Risks and Side Effects

While Imvexxy can be effective in treating dyspareunia, it is associated with some risks and side effects, including:

• Endometrial cancer: Estrogen-only therapy, like Imvexxy, may increase the risk of endometrial cancer, particularly in women with an intact uterus 3, 5, 6.
• Blood clots and stroke: Estrogen therapy may also increase the risk of blood clots and stroke, especially in women with a history of these conditions 2, 4.
• Breast cancer: Some studies suggest that estrogen therapy may increase the risk of breast cancer, although the evidence is not conclusive 3.

Important Considerations

It is essential to carefully weigh the benefits and risks of using Imvexxy and discuss any concerns with your healthcare provider.

• Women with a history of cancer, blood clots, or stroke should be closely monitored while using Imvexxy 2, 3, 4.
• Regular pelvic exams and Pap tests are necessary to monitor for any changes in the uterus or cervix 5, 6.