From the Guidelines
Rs1801181 CT is an indicator of a genetic variant associated with an increased risk of cardiovascular disease, particularly coronary heart disease (CHD) and myocardial infarction (MI). The association between this variant and increased cardiovascular risk is due to its location on chromosome 9p21.3, which is adjacent to genes that regulate senescence and apoptosis, such as CDKN2A, ARF, and CDKN2B 1. Some key points to consider about this variant include:
- The 9p21.3 genomic region has been widely replicated as a risk factor for CHD, with a 1.3- to 2.0-fold increased risk for MI observed in persons of various ethnicities, including European, Asian, and Hispanic descent 1.
- The mechanisms underlying the 9p21.3 association with CHD remain unclear, but the variants are thought to regulate senescence and apoptosis 1.
- The addition of the genotype to a model based on traditional CVD risk factors may not significantly improve risk discrimination, but it can result in better model fit and shift individuals into a more accurate risk category 1. It is essential to consider the clinical significance of this variant in the context of overall cardiovascular risk, as it is just one of many factors that contribute to an individual's risk of developing CHD or MI. Other factors, such as family history, serum lipid levels, and traditional CVD risk factors, should also be taken into account when assessing an individual's risk 1.
From the Research
rs1801181 CT Indicator
- rs1801181 CT is not directly mentioned in the provided studies as an indicator of a specific condition.
- However, the studies discuss the association between C-reactive protein (CRP) and cardiovascular disease risk 2, 3, 4, 5.
- CRP is a biomarker for inflammation and has been established as an independent risk factor for cardiovascular disease events 2.
- Certain genetic polymorphisms, such as those in the CRP gene, can influence CRP blood levels and may be associated with cardiovascular disease risk 3.
- Other studies have investigated the relationship between inflammation and cardiovascular disease, as well as the potential clinical utility of measuring CRP levels 4, 5.
- A separate study examined the association between a different genetic polymorphism (MTHFR rs1801133 C>T) and the risk of tetralogy of Fallot, a congenital heart disease 6.
- There is no direct evidence in the provided studies to suggest that rs1801181 CT is an indicator of a specific condition, and further research would be needed to determine its significance.