What are the risks associated with cryotherapy for treating plantar verrucae (plantar warts)?

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Last updated: May 13, 2025View editorial policy

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From the Guidelines

Cryotherapy for plantar warts carries significant risks, including pain, blistering, scarring, hypopigmentation, infection, and temporary nerve damage, and patients should be aware of these potential complications before undergoing treatment. The main risks associated with cryotherapy for plantar warts include:

  • Pain during and after the procedure, which can be significant as the foot sole has many nerve endings 1
  • Blistering commonly occurs at the treatment site, which may be uncomfortable when walking 1
  • Scarring is possible, though typically minimal with proper technique 1
  • Hypopigmentation (lightening of the skin) can occur, especially in darker skin tones, as the freezing damages melanocytes 1
  • There's also a risk of infection if blisters break open and aren't kept clean 1
  • Some patients experience temporary nerve damage resulting in numbness or tingling 1
  • The treatment may not completely remove the wart, requiring multiple sessions 1
  • Rarely, cryotherapy can cause tendon or nerve damage if applied too deeply, particularly in areas with thin skin covering these structures 1
  • People with certain conditions like peripheral vascular disease, diabetes, or Raynaud's phenomenon should approach cryotherapy with caution as they may have impaired healing or increased sensitivity to cold treatments 1

According to the most recent and highest quality study, the British Association of Dermatologists' guidelines for the management of cutaneous warts 2014 1, cryotherapy is a commonly used treatment for plantar warts, but it is essential to be aware of the potential risks and complications associated with this treatment. The guidelines recommend that healthcare providers be trained on the proper use of cryotherapy to minimize the risk of complications and ensure effective treatment.

From the Research

Risks of Cryotherapy for Plantar Warts

  • The provided studies do not directly discuss the risks associated with cryotherapy for plantar warts, but rather compare its effectiveness with other treatments 2, 3, 4, 5, 6.
  • However, it can be inferred that cryotherapy may have some risks, such as:
    • Pain or discomfort during and after the treatment
    • Potential for scarring or permanent damage to the skin
    • Risk of infection or other complications
  • Study 5 mentions that there were no serious complications of treatment with cryosurgery, but this may not be representative of all cases.
  • More research is needed to fully understand the risks associated with cryotherapy for plantar warts.

Comparison of Cryotherapy with Other Treatments

  • Cryotherapy has been compared with other treatments, such as salicylic acid 3, 4 and cantharidin-podophylotoxin-salicylic acid 6.
  • The effectiveness of cryotherapy varies depending on the study and the specific treatment being compared 2, 3, 4, 5, 6.
  • Some studies suggest that cryotherapy may be more effective than other treatments for certain types of warts, such as common warts 4.
  • However, the evidence is not consistent, and more research is needed to determine the most effective treatment for plantar warts.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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