From the Research
Fatigue from mononucleosis can last anywhere from 2-4 weeks to several months, with some cases persisting up to 6 months or longer, as reported in a study from 1. The severity and duration of fatigue vary significantly between individuals. During the first few weeks of illness, rest is crucial, and patients should avoid strenuous physical activity and contact sports for at least 4 weeks to prevent potential splenic rupture. Gradually increasing activity as energy improves is recommended, but pushing too hard can prolong recovery. There is no specific medication to treat mono fatigue; management focuses on supportive care including adequate hydration, balanced nutrition, and sufficient sleep. The fatigue occurs because the Epstein-Barr virus triggers an intense immune response that depletes energy reserves while the body fights the infection. Some studies, such as 2, suggest that supplementary management with Robuvit® may help reduce fatigue and improve symptoms related to mononucleosis. However, the use of corticosteroids for symptom relief in children with IM is not recommended, except in severe circumstances, as stated in 3. Patients should consult their healthcare provider if fatigue persists beyond 3-4 months or if symptoms suddenly worsen, as this could indicate complications or another underlying condition. Key factors to consider in managing mono fatigue include:
- Getting plenty of rest and avoiding strenuous activities
- Staying hydrated and maintaining a balanced diet
- Gradually increasing activity levels as energy improves
- Considering supplementary management options, such as Robuvit®, under the guidance of a healthcare provider
- Monitoring for potential complications or underlying conditions that may be contributing to persistent fatigue.