Differential Diagnosis for a Teenage Boy with Bilateral Uveitis and High Serum ACE
- Single most likely diagnosis
- Sarcoidosis: This is the most likely diagnosis due to the combination of bilateral uveitis and elevated serum angiotensin-converting enzyme (ACE) levels, which is a common finding in sarcoidosis. Sarcoidosis is a systemic granulomatous disease that can affect multiple organs, including the eyes, lungs, and skin.
- Other Likely diagnoses
- Tuberculosis: Although less common, tuberculosis (TB) can cause uveitis and elevated ACE levels. TB is a bacterial infection that can affect various parts of the body, including the lungs, brain, and eyes.
- Lymphoma: Some types of lymphoma, such as Hodgkin's lymphoma, can cause uveitis and elevated ACE levels. Lymphoma is a type of cancer that affects the immune system.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Syphilis: Syphilis is a bacterial infection that can cause uveitis and other systemic symptoms. Although less common, syphilis can have serious consequences if left untreated, including blindness and neurological damage.
- Lyme disease: Lyme disease is a bacterial infection that can cause uveitis and other systemic symptoms. If left untreated, Lyme disease can lead to serious complications, including arthritis, neurological damage, and heart problems.
- Rare diagnoses
- Blau syndrome: Blau syndrome is a rare genetic disorder that can cause uveitis, skin lesions, and other systemic symptoms. It is characterized by the presence of granulomatous inflammation in multiple organs.
- Crohn's disease: Crohn's disease is a type of inflammatory bowel disease that can cause uveitis and other extraintestinal symptoms. Although rare, Crohn's disease can cause significant morbidity if left untreated.