From the Guidelines
The starting dose of Vyvanse (lisdexamfetamine) should be 20-30 mg orally once daily in the morning. This recommendation is based on the most recent and highest quality study available, which suggests that the usual starting dose for lisdexamfetamine is between 20-30 mg po qam 1.
Key Considerations
- The dose may be titrated by increasing it by 10 mg weekly to a maximum of 70 mg daily, as needed and under medical supervision 1.
- It is essential to follow the doctor's specific dosing instructions, as they may recommend a different starting dose based on individual medical history and needs.
- Lisdexamfetamine is a prodrug that is converted to dextroamphetamine, and there is limited published information on its use in pregnancy and breastfeeding 1.
Important Details
- The medication should be taken consistently at the same time each day, with or without food.
- If a dose is missed, it should be taken as soon as remembered, but avoided late in the day to prevent difficulty sleeping.
- Common side effects of Vyvanse include insomnia, decreased appetite, and increased heart rate, which can be minimized by starting at a lower dose and gradually increasing it as needed.
From the FDA Drug Label
2.3 Dosage for Treatment of ADHD The recommended starting dosage in adults and pediatric patients 6 years and older is 30 mg once daily in the morning. 2.4 Dosage for Treatment of Moderate to Severe BED in Adults The recommended starting dosage in adults is 30 mg once daily to be titrated in increments of 20 mg at approximately weekly intervals to achieve the recommended target dose of 50 mg to 70 mg once daily.
The starting dose of Vyvanse is 30 mg once daily in the morning for both ADHD and moderate to severe BED in adults, and ADHD in pediatric patients 6 years and older 2.
From the Research
Starting Dose of Vyvanse
- The starting dose of Vyvanse (lisdexamfetamine) is not explicitly stated in the provided studies 3, 4, 5, 6, 7.
- However, study 3 mentions that patients were randomized to an optimized daily dose of LDX (30,50 or 70 mg).
- It can be inferred that the starting dose of Vyvanse may be 30 mg, as this is the lowest dose mentioned in the study 3.
- Further research is needed to confirm the starting dose of Vyvanse, as the provided studies do not provide a clear answer to this question.
Dosing Information
- Study 3 provides information on the dosing of LDX, with patients receiving 30,50, or 70 mg per day.
- Study 4 does not provide specific dosing information for LDX.
- Study 5 mentions that LDX was initiated at a dose of 30-70 mg per day, but does not provide further details.
- Study 6 does not provide specific dosing information for LDX.
- Study 7 does not provide specific dosing information for LDX, but discusses the molecular mechanisms of LDX and its effects on ADHD neurobiology.