From the FDA Drug Label
In Adults, 750 to 1750 mg/day in divided doses every 8 to 12 hours
- The dosing for adults with dental infection is not explicitly stated in the label, but the general dosing for adults is 750 to 1750 mg/day in divided doses every 8 to 12 hours 1.
- However, since dental infections are not explicitly mentioned, no conclusion can be drawn regarding the specific dosing for dental infections in adults.
From the Research
For adults with dental infections, the standard amoxicillin dosage is 875 mg twice daily for 7-10 days, as this regimen provides adequate coverage against the common bacteria involved in dental infections, according to the most recent and highest quality study 2.
Key Considerations
- The dosage may vary depending on the severity of the infection, with more severe infections potentially requiring a longer course of treatment.
- It is essential to take the full course of antibiotics, even if symptoms improve before completion, to ensure that the infection is fully cleared.
- Amoxicillin works by inhibiting bacterial cell wall synthesis, causing bacterial cell death, and is effective against many oral bacteria, including streptococci and anaerobes.
- Alongside antibiotics, dental treatment to address the source of infection, such as drainage, tooth extraction, or root canal, is crucial.
- Patients should stay hydrated, take medication with food to reduce stomach upset, and seek immediate medical attention if they develop severe pain, facial swelling, difficulty breathing or swallowing, or fever above 101°F.
Alternative Options
- If a patient has a penicillin allergy, alternatives include clindamycin (300-450 mg four times daily) or azithromycin (500 mg on day 1, then 250 mg daily for 4 more days) 3.
- The combination of amoxicillin and clavulanic acid has been shown to be effective in treating odontogenic infections, with a dosage of 875 mg/125 mg twice daily for 5-7 days 2.
Important Notes
- The use of antibiotics should be guided by comprehensive guidelines to reduce the risk of unnecessary prescriptions and bacterial resistance 3.
- Patients should be monitored for adverse reactions, such as hypersensitivity reactions, dermatological and allergic disorders, and gastrointestinal problems 3.