From the Guidelines
Triptorelin 11.25 mg should be administered every 84 days, as this dosing schedule is not supported by the provided evidence, which recommends a dose of 11.25 mg once every 12 weeks for the Trelstar mixject (triptorelin) formulation 1. The standard dosing schedule for triptorelin varies depending on the specific formulation and the condition being treated.
- The Trelstar mixject (triptorelin) formulation is available in doses of 3.75 mg once every 4 weeks, 11.25 mg once every 12 weeks, and 22.5 mg once every 24 weeks 1.
- The provided evidence does not support the administration of triptorelin 11.25 mg every 84 days, but rather every 12 weeks for the 3-month depot preparation 1.
- Triptorelin is a gonadotropin-releasing hormone (GnRH) agonist used to treat hormone-responsive conditions such as prostate cancer, endometriosis, uterine fibroids, or precocious puberty.
- Patients should maintain regular follow-up appointments to monitor response to therapy and manage any potential side effects, and it's essential not to miss scheduled injections to ensure continuous hormone suppression for optimal therapeutic effect.
- The cost of triptorelin varies depending on the formulation, dose, and schedule, with the 11.25 mg once every 12 weeks formulation costing $610.19 for GPO pricing, $126.54 for 340B pricing, and $847.92 for Medicare, with a 6-month total cost of $1,695.84 1.
From the Research
Administration of Triptorelin
- The administration of triptorelin varies based on the condition being treated and the specific formulation used.
- For advanced prostate cancer, a dosage of 11.25 mg triptorelin was injected on Day 0 and repeated on Day 90 2.
- In the treatment of central precocious puberty, triptorelin 11.25 mg was administered every 90 days 3.
- There is no evidence to suggest that 11.25 mg triptorelin is given every 84 days, however, it is given every 90 days in some cases 2, 3.
Dosage Interval
- The dosage interval of triptorelin can vary, with some studies using a 4-week interval 4 and others using a 6-week interval 5, 6 or a 3-month interval 2, 3.
- The specific dosage interval used may depend on the condition being treated and the individual patient's response to the medication.
Efficacy of Triptorelin
- Triptorelin has been shown to be effective in achieving medical castration and lowering PSA concentrations in patients with advanced prostate cancer 2.
- It has also been shown to be effective in suppressing gonadotropin and sex steroid secretion and pubertal signs in children with central precocious puberty 3.
- The efficacy of triptorelin has been demonstrated in various studies, with different dosage intervals and formulations used 2, 5, 6, 4, 3.