What is the differential diagnosis (DDX) of a painful breast lump in a 12-year-old female?

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Differential Diagnosis for a Painful Breast Lump in a 12-Year-Old

Single Most Likely Diagnosis

  • Breast bud tenderness or Thelarche: This is the most common cause of breast lumps in adolescent girls, occurring as a result of hormonal changes during puberty, leading to breast development and sometimes tenderness.

Other Likely Diagnoses

  • Fibroadenoma: A common benign breast tumor in adolescents, often presenting as a firm, mobile, and sometimes tender lump.
  • Cyst: Breast cysts can occur in adolescents, although less commonly than in adults, and may cause pain, especially if they become large or rupture.
  • Infection or Abscess: Breast infections can occur in adolescents, particularly if they have a history of trauma, surgery, or are breastfeeding (less common in this age group).
  • Fat Necrosis: Trauma to the breast can cause fat necrosis, leading to a painful lump.

Do Not Miss Diagnoses

  • Breast Cancer: Although extremely rare in adolescents, breast cancer must be considered to avoid delayed diagnosis. It's crucial to investigate any persistent or growing lump.
  • Phyllodes Tumor: A rare type of breast tumor that can be benign, borderline, or malignant. It tends to grow quickly and can cause pain.
  • Potts Disease (Tuberculous Mastitis): In areas where tuberculosis is common, tuberculous mastitis should be considered, especially if there's a history of exposure or systemic symptoms.

Rare Diagnoses

  • Hamartoma: A benign breast tumor composed of a mixture of glandular, fibrous, and fatty tissues, which is rare in adolescents.
  • Papilloma: Benign tumors growing in the milk ducts of the breast, which can cause a lump and are more common in older women but can occasionally occur in adolescents.
  • Lipoma: A rare benign tumor made up of fat tissue, which can occur in the breast and cause a lump.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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