From the Guidelines
Inclisiran does not deactivate when stored in a refrigerator, and in fact, it should be stored at 2-8°C to maintain its stability. According to the storage and transportation guidelines for PCSK9 inhibitors, inclisiran should be stored and transported at 2-8°C and avoid sunshine and freezing 1. This is crucial to prevent degradation of the small interfering RNA (siRNA) molecule, which is the active component of inclisiran.
- The recommended storage conditions for inclisiran are designed to protect the medication from light and temperature fluctuations, ensuring its potency and efficacy.
- If inclisiran is stored at room temperature, it is essential to use it within a short period, typically up to 30 days, to maintain its stability.
- It is also important to check the expiration date before administration, as proper storage alone cannot extend the medication beyond its shelf life.
- Additionally, if the medication appears discolored or contains particles, it should not be used regardless of storage conditions, to ensure patient safety and prevent potential adverse effects.
From the Research
Storage and Stability of Inclisiran
- There is no direct information available in the provided studies regarding the effect of refrigeration on the stability of inclisiran.
- The studies primarily focus on the efficacy, safety, and mechanism of action of inclisiran in treating hypercholesterolemia 2, 3, 4, 5, 6.
- None of the studies mention the storage conditions or the impact of refrigeration on the drug's activity.
- Therefore, it is not possible to determine whether inclisiran deactivates when put in a fridge based on the available evidence.