What is the differential diagnosis of a breast lump?

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Last updated: May 14, 2025View editorial policy

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Breast Lump Differential Diagnosis

The differential diagnosis for a breast lump can be organized into the following categories:

  • Single Most Likely Diagnosis
    • Fibroadenoma: This is a common benign breast tumor, especially in young women. It is usually a firm, mobile, and painless lump.
  • Other Likely Diagnoses
    • Cyst: A breast cyst is a fluid-filled sac that can feel like a lump. It is often tender and can change size with the menstrual cycle.
    • Lipoma: A lipoma is a benign tumor made of fat tissue. It is usually soft and mobile.
    • Fibrocystic changes: These are non-cancerous changes in the breast tissue that can cause lumps, tenderness, and nipple discharge.
    • Breast abscess: An abscess is a collection of pus that can cause a lump, pain, and redness in the breast.
  • Do Not Miss Diagnoses
    • Breast cancer: Although less likely, breast cancer is a critical diagnosis that must be considered, especially in older women or those with a family history.
    • Phyllodes tumor: A phyllodes tumor is a rare tumor that can be benign, borderline, or malignant. It can grow quickly and cause a large lump.
    • Inflammatory breast cancer: This is a rare and aggressive type of breast cancer that can cause a lump, redness, and swelling in the breast.
  • Rare Diagnoses
    • Hamartoma: A hamartoma is a rare benign tumor that can cause a lump in the breast.
    • Pseudoangiomatous stromal hyperplasia (PASH): PASH is a rare benign condition that can cause a lump in the breast.
    • Metastasis to the breast: Although rare, cancer from other parts of the body can metastasize to the breast and cause a lump.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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