From the Guidelines
Creatine supplementation is not recommended for neonates due to the lack of clinical evidence supporting its use in this population. The current evidence, as seen in a review published in The Lancet Neurology 1, does not establish a clear benefit of creatine supplementation, even in conditions like Duchenne muscular dystrophy, and highlights the need for caution, especially in patients with renal dysfunction.
Key Considerations
- The role of creatine in cellular energy metabolism and brain development is well understood, but its application in neonates is not supported by sufficient clinical data.
- There are no established dosing regimens for neonatal creatine supplementation, making it impractical for routine use.
- For supporting neonatal development, focusing on established practices such as adequate nutrition through breastfeeding or appropriate formula, skin-to-skin contact, and following pediatrician recommendations is preferable.
Safety and Efficacy
- The safety profile and long-term outcomes of creatine supplementation in neonates are largely unknown, necessitating a cautious approach.
- Any potential neuroprotective effects of creatine during hypoxic stress are theoretical and require further investigation within controlled clinical settings.
Clinical Approach
- Parents interested in creatine supplementation for their newborns should be advised on the lack of evidence and the importance of adhering to established care practices.
- Consideration of creatine for specific neonatal conditions should only occur under close medical supervision, ideally within clinical trials or specialized settings where safety and efficacy can be closely monitored 1.
From the Research
Creatine Supplementation
- There is no direct evidence to suggest that creatine supplementation has neonatal benefits 2, 3.
- The existing research on creatine supplementation focuses on its effects on muscle performance and exercise capacity in adults and athletes 2, 3.
Omega-3 Fatty Acids and Neonatal Benefits
- Omega-3 fatty acids have been shown to be essential for brain development and function, and may have a role in reducing symptoms of neurodevelopmental disorders 4, 5, 6.
- Studies have found that omega-3 fatty acid supplementation may alleviate symptoms of attention-deficit/hyperactivity disorder (ADHD) and other neurodevelopmental disorders in children 4, 6.
- Research has also shown that omega-3 fatty acid supplementation may be beneficial for neonatal rats exposed to intermittent hypoxia, reducing oxidative stress and inflammation in the brain 5.
Comparison of Creatine and Omega-3 Fatty Acids
- While creatine supplementation has been extensively studied in adults and athletes, there is limited research on its effects on neonates 2, 3.
- In contrast, omega-3 fatty acids have been shown to have potential benefits for neonatal development and may reduce the risk of neurodevelopmental disorders 4, 5, 6.