What is the significance of a heterogeneous, cystic appearance of the endometrium, potentially indicating cystic endometrial hyperplasia, and nonspecific myometrial heterogeneity, possibly related to adenomyosis?

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Last updated: May 14, 2025View editorial policy

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Differential Diagnosis

  • Single most likely diagnosis
    • Cystic endometrial hyperplasia: This condition is suggested by the heterogeneous, cystic appearance of the endometrium, which is a common finding in endometrial hyperplasia.
  • Other Likely diagnoses
    • Adenomyosis: The nonspecific myometrial heterogeneity could be related to adenomyosis, a condition where endometrial tissue grows into the uterine wall.
    • Endometrial polyps: These growths can cause a heterogeneous, cystic appearance of the endometrium and are a common finding in women of reproductive age.
    • Submucosal fibroids: Although not directly mentioned, submucosal fibroids can cause heterogeneity of the endometrium and myometrium.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Endometrial carcinoma: Although neoplasia is not excluded, endometrial carcinoma is a potentially life-threatening condition that requires prompt diagnosis and treatment.
    • Uterine sarcoma: A rare but aggressive type of cancer that can present with similar symptoms and imaging findings.
  • Rare diagnoses
    • Endometrial metastasis: Metastasis to the endometrium from other cancers is rare, but can occur, and would require prompt diagnosis and treatment.
    • Uterine lymphoma: A rare type of cancer that can affect the uterus and present with nonspecific imaging findings.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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