What is the recommended dose of Prednisone (prednisone) for acute sinusitis?

From the Guidelines

For acute sinusitis, the recommended dose of Prednisone is 40-60mg for 3 days, with the dose adjusted based on body weight (40mg for 40-60kg, 60mg for 60-80kg, and 80mg for >80kg), as this regimen has been shown to significantly reduce mean pain intensity difference, nasal obstruction, and use of paracetamol at day 1-3 1. The evidence from the study by Klossek 2004, as cited in the european position paper on rhinosinusitis and nasal polyps 2020 1, supports the use of Prednisone in this dosage for acute sinusitis. Some key points to consider when prescribing Prednisone for acute sinusitis include:

• Starting with a higher dose and tapering down over the course of treatment may not be necessary, as the study by Klossek 2004 used a fixed dose for 3 days 1
• Taking the medication in the morning with food can help minimize side effects
• Completing the full course as prescribed is crucial, even if symptoms improve, to avoid adrenal insufficiency
• Prednisone should be used judiciously due to potential side effects, and it's often reserved for severe cases or when other treatments have failed
• If symptoms persist after treatment, further evaluation by a doctor is necessary. It's also important to note that other studies, such as Venekamp et al. 2012 and Gehanno 2000, did not show significant benefits of systemic corticosteroids in patients with acute post-viral rhinosinusitis 1, but the study by Klossek 2004 provides the most relevant evidence for the recommended dose of Prednisone.

From the Research

Recommended Dose of Prednisone for Acute Sinusitis

The recommended dose of prednisone for acute sinusitis is not explicitly stated in the provided studies. However, the following information can be gathered:

• The studies 2, 3 mention that participants were assigned to either oral corticosteroids (prednisone 24 mg to 80 mg daily or betamethasone 1 mg daily) or the control treatment.
• The dose of prednisone used in the studies ranges from 24 mg to 80 mg daily.
• The studies do not provide a specific recommendation for the dose of prednisone for acute sinusitis.

Key Findings

• The use of oral corticosteroids, including prednisone, as an adjunctive therapy to oral antibiotics may be modestly beneficial for short-term relief of symptoms in acute sinusitis 2, 3.
• The evidence suggests that oral corticosteroids as a monotherapy appear to be ineffective for adult patients with clinically diagnosed acute sinusitis 2.
• The studies do not provide information on the long-term effects of oral corticosteroids on acute sinusitis, such as effects on relapse or recurrence rates 2, 3.

Study Limitations

• The studies have limitations, including high statistical heterogeneity and a significant risk of bias 2, 3.
• The studies do not provide data on the long-term effects of oral corticosteroids on acute sinusitis 2, 3.
• The evidence is limited, and more research is needed to establish the effectiveness of oral corticosteroids for acute sinusitis 2, 3.