From the Guidelines
Dulera should be administered at a dose of 2 inhalations twice daily, with the strength of 100/5 mcg or 200/5 mcg per actuation determined by the patient's asthma severity, as prescribed by a doctor. When considering the management of asthma or COPD, it's crucial to prioritize treatments that improve morbidity, mortality, and quality of life. In the context of Dulera, which combines a corticosteroid (mometasone furoate) and a long-acting beta-agonist (formoterol fumarate), the dosing is critical for effective disease management. The standard regimen for adults and children 12 years and older is 2 inhalations twice daily, morning and evening, with the specific strength (100/5 mcg or 200/5 mcg per actuation) tailored to the individual's disease severity. Key points to consider when prescribing Dulera include:
- The importance of regular, consistent use to maintain control over asthma symptoms, even in the absence of symptoms.
- The need to rinse the mouth with water after each use to prevent oral thrush.
- Dulera is not intended for rescue use in sudden breathing problems; a separate rescue inhaler should always be available. While the provided evidence 1 focuses on the prevention of acute exacerbations of COPD using long-acting bronchodilators, the principles of managing chronic respiratory disease with a focus on quality of life, morbidity, and mortality are relevant. The evidence highlights the benefits of long-acting beta-agonists in reducing exacerbation rates and improving quality of life in patients with COPD, which can inform the use of similar medications in asthma management, such as the formoterol component in Dulera. However, the specific dosing and management recommendations for Dulera are based on its approved use and clinical guidelines for asthma treatment.
From the Research
Dulera Dose Information
- The recommended dose of Dulera, a combination of mometasone furoate and formoterol fumarate, varies depending on the patient's condition and response to treatment 2, 3, 4.
- For patients with moderate to very severe chronic obstructive pulmonary disease (COPD), the recommended dose is 400/10 μg or 200/10 μg twice daily 2, 3, 4.
- For patients with persistent asthma, the recommended dose is 200/10 μg or 400/10 μg twice daily 5.
- The dose of Dulera should be individualized and titrated to the lowest effective dose to control symptoms and minimize side effects 2, 3, 4, 5.
Efficacy and Safety
- Studies have shown that Dulera is effective in improving lung function, reducing symptoms, and improving quality of life in patients with COPD and asthma 2, 3, 4, 5.
- The safety profile of Dulera is similar to that of other inhaled corticosteroids and long-acting beta2-agonists, with common side effects including headache, dysphonia, and oral candidiasis 2, 3, 4, 5.
- Long-term safety studies have shown that Dulera is well-tolerated and effective for up to 1 year of treatment 5.