From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
For uncomplicated urinary tract infections (UTIs) in adults, the standard cefdinir dosing is 300 mg twice daily for 7-10 days, as supported by the most recent study 1. This dosing regimen is effective against many common UTI pathogens, including E. coli. Some key points to consider when prescribing cefdinir for UTIs include:
- The dose for children is 14 mg/kg/day divided into two doses (maximum 600 mg/day) for 10 days.
- Cefdinir can be taken with or without food, but taking it with food may improve gastrointestinal tolerance.
- Patients with renal impairment (creatinine clearance <30 mL/min) should receive a reduced dose of 300 mg once daily.
- Common side effects of cefdinir include diarrhea, nausea, and headache.
- It is essential for patients to complete the full course of antibiotics, even if symptoms improve before finishing treatment, to ensure complete eradication of the infection and prevent recurrence. The study by 1 compared cefdinir and cephalexin for the treatment of UTIs and found no significant differences in treatment failure between the two agents, suggesting that cefdinir is a viable option for UTI treatment. However, local resistance patterns may vary, and cefdinir may not be the first-line treatment for UTIs in all regions, as noted in other studies 2, 3, 4, 5. Overall, cefdinir is a third-generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis, making it effective against many common UTI pathogens.