From the FDA Drug Label
To achieve maximum contraceptive effectiveness, norethindrone tablets must be taken exactly as directed. One tablet is taken every day, at the same time. Administration is continuous, with no interruption between pill packs. The dose of norethindrone to prevent period is one tablet every day, taken at the same time.
- The tablets should be dispensed in a way that allows for continuous administration, with no interruption between pill packs 1.
From the Research
To prevent menstrual periods using norethindrone, the most effective dose is 5 mg taken orally three times daily, as supported by the most recent study 2. This medication should be dispensed as prescribed by a healthcare provider, usually in tablet form, with instructions to take it at the same time each day for consistent hormone levels. The prescription typically comes in a bottle containing 30-90 tablets depending on the duration of treatment. When starting norethindrone for menstrual suppression, it's best to begin on or before cycle day 12, or after confirming you're not pregnant. For continuous use to prevent periods, the medication is taken without breaks. Norethindrone works by providing a steady level of progestin hormone, which thins the uterine lining and prevents it from building up and shedding during a period. Some key points to consider when prescribing norethindrone for menstrual suppression include:
- Patient satisfaction is significantly higher with norethindrone compared to combined oral contraceptives 2
- Norethindrone may cause weight gain, which resolves after cessation of therapy, and heavier withdrawal bleeding 2
- Time to conceive is significantly shorter in the norethindrone group 2
- Obesity, heavy menstrual bleeding, and younger age may be negatively associated with achieving menstrual suppression, and higher doses of norethindrone acetate may be needed in these cases 3 Side effects may include irregular bleeding, especially during the first few months, headaches, nausea, breast tenderness, and mood changes. This medication doesn't provide contraception at this dose, so additional birth control may be needed if pregnancy prevention is desired. Always consult with a healthcare provider before starting this medication, as individual dosing may vary based on your specific health needs.