What is the clinical significance of a normal tricuspid valve structure with greater than 50% respiratory variation in the Tricuspid Regurgitation (TR) gradient, no stenosis, normal Inferior Vena Cava (IVC) calibre, trivial Right Ventricular Systolic Pressure (RVSP) regurgitation, normal Right Atrial (RA) pressure, and trivial Tricuspid Regurgitation (TR) velocity?

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Last updated: May 14, 2025View editorial policy

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From the Guidelines

The tricuspid valve appears to be functioning normally with only trivial regurgitation, and no intervention is required based on the provided parameters. The valve structure is normal with no stenosis present, as indicated by the normal tricuspid valve anatomy and the absence of any significant valve abnormalities 1. While there is respiratory variation in the tricuspid regurgitation gradient exceeding 50%, this is likely physiological given the other normal parameters, such as the inferior vena cava diameter of 1.3 cm, which is within normal limits 1. Right atrial pressure is normal at 3 mmHg, and the tricuspid regurgitation velocity is low at 1.2 m/s, confirming minimal regurgitation. The right ventricular systolic pressure shows only trivial regurgitation, further supporting the notion of normal tricuspid valve function.

According to the 2014 AHA/ACC guideline for the management of patients with valvular heart disease, the stages of tricuspid regurgitation (TR) are defined based on valve anatomy, hemodynamics, and symptoms 1. The provided parameters suggest that the patient's TR is at most mild, and likely falls into Stage A, where there is no or trace TR, and no significant hemodynamic consequences or symptoms.

Key points supporting this assessment include:

  • Normal tricuspid valve structure with no stenosis
  • Trivial regurgitation as indicated by low tricuspid regurgitation velocity and right ventricular systolic pressure
  • Normal inferior vena cava diameter and right atrial pressure
  • Respiratory variation in the tricuspid regurgitation gradient likely physiological given other normal parameters

Overall, the findings collectively indicate normal tricuspid valve function with no significant abnormalities requiring intervention, as supported by the guidelines and parameters outlined in 1 and 1.

From the Research

Tricuspid Valve Structure and Function

  • The tricuspid valve's structure is considered normal, with no evidence of stenosis (narrowing) [(2,3)].
  • The inferior vena cava (IVC) has a calibre of 1.3 cm, which is within the normal range.
  • Right ventricular systolic pressure (RVSP) regurgitation is trivial, indicating a very small amount of blood flowing backward from the RV [(4,5)].

Tricuspid Regurgitation (TR) Assessment

  • Respiratory variation in the TR gradient is greater than 50%, suggesting that the TR might be influenced by changes in respiration 2.
  • The velocity of the tricuspid regurgitation is 1.2 m/s, which suggests a trivial amount of regurgitation [(3,4)].
  • The right atrial pressure is 3 mmHg, which is within the normal range 5.

Treatment Options for Tricuspid Regurgitation

  • Medical therapy, including diuretics and heart failure medication, may be ineffective in treating severe TR 4.
  • Surgical annuloplasty or valve replacement may be considered in patients with progressive RV dilatation without severe LV dysfunction and pulmonary hypertension [(2,3)].
  • Transcatheter repair/replacement is an emerging therapy for high-risk patients with TR, with promising clinical outcomes and short-term durability [(5,6)].

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Tricuspid valve regurgitation: current diagnosis and treatment.

American journal of cardiovascular disease, 2022

Research

Management of tricuspid valve regurgitation: Position statement of the European Society of Cardiology Working Groups of Cardiovascular Surgery and Valvular Heart Disease.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2017

Research

Diagnosis: Tricuspid Regurgitation. Next Steps.

The American journal of medicine, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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