From the Research
DHEA (dehydroepiandrosterone) should not be taken with spironolactone without consulting a healthcare provider first, as it may counteract the hormonal effects of spironolactone therapy. DHEA is a hormone produced by the adrenal glands that serves as a precursor to both male and female sex hormones. It's often taken as a supplement for various purposes including addressing hormonal imbalances, improving energy, and supporting overall well-being. When considering taking DHEA with spironolactone, it's essential to understand the potential interactions between these medications. Spironolactone is an anti-androgen medication that blocks testosterone effects, while DHEA can increase hormone levels including testosterone, as shown in a meta-analysis of 42 publications 1.
Key Considerations
- The combination of DHEA and spironolactone may reduce the effectiveness of spironolactone therapy, as DHEA can increase testosterone levels, which may counteract the anti-androgenic effects of spironolactone.
- A study published in 2020 found that DHEA supplementation significantly increased testosterone levels, with a weighted mean difference of 28.02 ng/dl 1.
- The effects of spironolactone on adrenal steroidogenesis have been studied, and it has been found to inhibit the production of androstenedione, but not DHEA, in hirsute women 2.
- Another study found that spironolactone decreased the levels of testosterone in some women, but the effect on DHEA levels was variable 3.
Recommendations
- If you're considering taking DHEA with spironolactone, consult with your healthcare provider first to determine appropriate dosing and monitoring.
- Your healthcare provider may recommend specific timing between doses, dosage adjustments, or regular blood tests to monitor hormone levels.
- The combination of DHEA and spironolactone may be contraindicated depending on your specific medical condition and treatment goals, as DHEA could potentially counteract the hormonal effects that spironolactone is intended to produce.