What is the cause of ascites in a patient with signs of heart failure and a water bottle heart (cardiomegaly), but without liver cirrhosis?

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Last updated: May 14, 2025 • View editorial policy

Differential Diagnosis for Ascites with Heart Failure and Water Bottle Heart

  • Single most likely diagnosis + Congestive heart failure (CHF) due to constrictive pericarditis: This condition is characterized by the accumulation of fluid in the pericardial space, leading to impaired diastolic filling of the heart. The "water bottle heart" description is classic for constrictive pericarditis, and ascites can occur due to increased venous pressure.
  • Other Likely diagnoses + Cardiac tamponade: Although less likely than constrictive pericarditis given the "water bottle heart" description, cardiac tamponade can still cause ascites and signs of heart failure. + Restrictive cardiomyopathy: This condition can mimic constrictive pericarditis and cause similar symptoms, including ascites and heart failure. + Tricuspid regurgitation: Severe tricuspid regurgitation can lead to right-sided heart failure, causing ascites.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.) + Cardiac lymphoma or metastasis: Malignant infiltration of the heart or pericardium can cause constrictive pericarditis or tamponade, leading to ascites and heart failure. + Tuberculous pericarditis: This condition can cause constrictive pericarditis and is often associated with a high mortality rate if left untreated.
  • Rare diagnoses + Pericardial effusion due to uremia: Although rare, uremic pericarditis can cause a large pericardial effusion, leading to cardiac tamponade and ascites. + Sarcoidosis with cardiac involvement: Sarcoidosis can cause constrictive pericarditis or restrictive cardiomyopathy, leading to ascites and heart failure.

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