What is the cause of anosmia in a patient with a history of canal removal and no mucosal sinus disease?

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Differential Diagnosis for Decreased Sense of Smell

  • Single most likely diagnosis
    • Post-traumatic olfactory dysfunction: The patient has a history of a canal being removed years ago, which could have damaged the olfactory nerves, leading to a decreased sense of smell.
  • Other Likely diagnoses
    • Viral upper respiratory infection: The patient's symptoms started in November, which is a common time for upper respiratory infections, and the decreased sense of smell could be a lingering effect.
    • Chronic rhinosinusitis: Although the sinuses appear clear on the imaging, chronic rhinosinusitis can cause a decrease in the sense of smell, and the patient may not have been experiencing active symptoms at the time of the scan.
    • Nasal polyposis: The imaging does not show any evidence of nasal polyposis, but it is possible that the patient has a small polyp or other nasal obstruction that is not visible on the scan.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Meningioma: Although the imaging does not show any evidence of a tumor, a meningioma in the anterior cranial fossa could cause a decrease in the sense of smell, and it is essential to consider this possibility to avoid missing a potentially life-threatening diagnosis.
    • Esthesioneuroblastoma: This is a rare tumor that originates in the olfactory nerves and can cause a decrease in the sense of smell, and it is crucial to consider this possibility to avoid missing a potentially life-threatening diagnosis.
  • Rare diagnoses
    • Kallmann syndrome: This is a rare genetic disorder that affects the development of the olfactory nerves and can cause a decrease in the sense of smell, but it is typically diagnosed in childhood or adolescence.
    • Traumatic injury to the olfactory nerves: Although the patient has a history of a canal being removed, it is possible that the patient experienced a traumatic injury to the olfactory nerves that is not related to the previous surgery.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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