From the Research
There is no established direct relation between aspartame and Alzheimer's disease based on current scientific evidence. Aspartame is an artificial sweetener found in many diet products and has been extensively studied for safety 1. While some preliminary animal studies have suggested potential concerns about aspartame's metabolites affecting brain function, these findings have not been conclusively demonstrated in humans. The development of Alzheimer's disease involves complex genetic, environmental, and lifestyle factors, with the primary risk factors being age, family history, and certain genetic mutations.
Key Points to Consider
- The most recent and highest quality study on aspartame safety found no evidence to support an association between aspartame and cancer in any tissue, and the weight of existing evidence is that aspartame is safe at current levels of consumption as a nonnutritive sweetener 1.
- A 2023 review of aspartame safety found some evidence of subtle mood and behavioral changes upon daily high-dose intake, but the association between aspartame intake and malignant diseases is still unclear and may be due to chance 2.
- If you're concerned about brain health, focus on established protective factors:
- regular physical exercise
- a Mediterranean-style diet rich in fruits, vegetables, and healthy fats
- mental stimulation
- social engagement
- management of cardiovascular risk factors like high blood pressure and diabetes These approaches have stronger scientific support for brain health than avoiding aspartame 3.
Recommendations for Brain Health
If you have specific concerns about your cognitive health, consulting with a healthcare provider is recommended rather than focusing on eliminating aspartame from your diet. Donepezil, a cholinesterase inhibitor, has been shown to have small benefits in cognitive function, activities of daily living, and clinician-rated global clinical state in people with mild, moderate, or severe dementia due to Alzheimer's disease 3. However, the use of donepezil should be weighed against its potential adverse events, and the decision to use it should be made in consultation with a healthcare provider.