Can discontinuation of ability (Antipsychotic medication) cause xerostomia (dry mouth)?

From the Guidelines

Discontinuation of ability, such as Abilify, is not directly associated with dry mouth as a common withdrawal symptom, according to the provided evidence 1. When considering the discontinuation of medications like Abilify, it's essential to focus on the potential withdrawal symptoms and the appropriate tapering schedule to minimize these effects.

• The provided evidence 1 discusses the importance of gradual tapering to avoid withdrawal symptoms or rebound worsening of symptoms.
• It emphasizes the need for a careful approach when discontinuing multiple medications, considering the underlying condition, the sequence of medication initiation, and the potential for withdrawal symptoms.
• However, the evidence does not specifically mention dry mouth as a common withdrawal symptom associated with the discontinuation of ability or similar medications.
• In clinical practice, when stopping medications that may have an impact on neurotransmitter systems, patients should be monitored for various withdrawal symptoms, and a gradual tapering schedule should be implemented to minimize potential effects, including any less common symptoms like dry mouth.
• If dry mouth or other symptoms occur during the discontinuation process, patients should consult their healthcare provider for guidance on managing these symptoms, which may include staying hydrated, using sugar-free lozenges, or artificial saliva products.

From the Research

Discontinuation of Ability and Dry Mouth

• The relationship between discontinuation of ability and dry mouth is not directly addressed in the provided studies.
• However, the studies discuss various causes of xerostomia (dry mouth), including medications with anticholinergic properties, dehydration, diabetes, and radiotherapy for head and neck cancer 2, 3, 4.
• It is possible that discontinuation of certain abilities or functions, such as salivary gland function, could contribute to dry mouth, but this is not explicitly stated in the studies.
• The studies focus on the management and treatment of xerostomia, including the use of salivary stimulants, salivary substitutes, and other treatment modalities 2, 3, 5, 6.

Causes of Xerostomia

• The most common causes of xerostomia include:
  • Medications with anticholinergic properties 2, 3, 6
  • Dehydration 2
  • Diabetes 2
  • Radiotherapy for head and neck cancer 2, 4
  • Systematic diseases, such as Sjögren's syndrome 4

Treatment of Xerostomia

• Treatment of xerostomia typically involves addressing the underlying cause, followed by the use of salivary substitutes and/or salivary stimulants 2, 6.
• Pilocarpine is considered a effective sialogogue drug for subjects with xerostomia due to radiation on head and neck cancer or diseases such as Sjögren's Syndrome 6.
• Lubrication of oral mucous membrane can reduce symptoms, although the effects are short-lived 6.