Differential Diagnosis for Lateral Leg Numbness when Standing
- Single most likely diagnosis
- Peroneal nerve compression: This condition is a common cause of lateral leg numbness, especially when standing. The peroneal nerve can be compressed at the fibular head, leading to numbness and weakness in the lateral aspect of the leg.
- Other Likely diagnoses
- L5 radiculopathy: Compression or irritation of the L5 nerve root can cause numbness and weakness in the lateral leg, which may worsen when standing.
- Peripheral neuropathy: Conditions such as diabetes or vitamin deficiencies can cause peripheral neuropathy, leading to numbness and tingling in the legs, including the lateral aspect.
- Lumbar spinal stenosis: Narrowing of the lumbar spinal canal can cause numbness and weakness in the legs, including the lateral aspect, which may worsen when standing.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Cauda equina syndrome: A rare but serious condition caused by compression of the cauda equina, which can lead to numbness, weakness, and loss of bladder and bowel function.
- Spinal tumor or infection: Although rare, spinal tumors or infections can cause numbness and weakness in the legs, including the lateral aspect, and require prompt medical attention.
- Rare diagnoses
- Meralgia paresthetica: A condition caused by compression of the lateral femoral cutaneous nerve, leading to numbness and tingling in the lateral thigh.
- Neuropathy due to vasculitis: Certain types of vasculitis, such as polyarteritis nodosa, can cause neuropathy and numbness in the legs, including the lateral aspect.
- Nutritional deficiencies (e.g., vitamin B12 deficiency): Although rare, nutritional deficiencies can cause peripheral neuropathy and numbness in the legs, including the lateral aspect.