From the Guidelines
Topical clindamycin should be applied as a 1% formulation once daily to the entire affected area lightly. This recommendation is based on the guidelines of care for the management of acne vulgaris, which suggests applying a thin film of clindamycin once daily to the skin where acne lesions appear 1. The dosing instructions emphasize covering the entire affected area lightly, without specifying an exact amount.
Key Considerations
- The treatment should be applied thinly to the affected area once daily.
- A 1% formulation of clindamycin is recommended for topical application in the treatment of acne vulgaris.
- The efficacy of 1% topical clindamycin gel has been demonstrated in a 12-week controlled clinical trial, showing it to be more effective than the vehicle applied once daily 1.
Potential Side Effects and Interactions
- Severe colitis, dermatitis, folliculitis, photosensitivity reaction, pruritus, erythema, dry skin, and peeling are potential adverse effects of topical clindamycin 1.
- Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents, highlighting the need for caution with certain interactions 1.
From the FDA Drug Label
Apply a thin film of Clindamycin Phosphate Topical Solution, Clindamycin Phosphate Lotion, or Clindamycin Phosphate Gel twice daily to affected area. The topical clindamycin dose is to apply a thin film of the solution, lotion, or gel to the affected area twice daily 2.
- Dose frequency: twice daily
- Dose application: thin film to affected area
From the Research
Topical Clindamycin Dose
- The provided studies do not specifically mention the topical clindamycin dose 3, 4, 5, 6, 7.
- The studies focus on the use of clindamycin in treating various infections, including skin and soft tissue infections, and its efficacy and tolerance in different patient groups 4, 5, 7.
- However, none of the studies provide information on the topical dose of clindamycin, suggesting that the available evidence may not be directly relevant to answering this question 3, 4, 5, 6, 7.
Available Information
- Clindamycin is an antibiotic used to treat anaerobic and severe complicated infections 3.
- It has been shown to be effective in treating streptococcal pyoderma and other skin infections 4, 5.
- The drug has good activity against methicillin-susceptible Staphylococcus aureus and streptococci, but resistance has been reported in some cases 5.