From the Research
Mycoplasma infections during pregnancy should be treated with azithromycin as the first-line treatment, as recommended by the most recent guidelines 1. The treatment of Mycoplasma genitalium infection in pregnancy is crucial to prevent complications such as preterm birth, low birth weight, or postpartum endometritis.
- The recommended treatment is typically azithromycin, which is considered safe during all trimesters of pregnancy 1.
- The dosing schedule of azithromycin may vary, but a common regimen is 1 gram as a single dose or 500 mg on day 1 followed by 250 mg daily for 4 more days 2.
- Alternative options, such as pristinamycin, may be considered for macrolide-resistant infections, but the safety data is inconsistent 1.
- It is essential to complete the full course of antibiotics, even if symptoms improve, and to treat partners simultaneously to prevent reinfection.
- Untreated mycoplasma infections during pregnancy can lead to severe complications, making prompt and effective treatment crucial 3, 4.
- The infection is diagnosed through specific PCR testing, as standard cultures do not detect mycoplasma 5.
- Macrolides like azithromycin are the preferred treatment option because mycoplasma bacteria lack cell walls, making them naturally resistant to common antibiotics like penicillins and cephalosporins that target cell wall synthesis 1, 2.