From the Guidelines
Metrogel 1% is a recommended treatment for rosacea, as it has been shown to be effective in reducing inflammatory lesions and perilesional erythema associated with the condition. According to a recent review of the current treatment landscape for rosacea, metronidazole 1% formulations have been well studied in more than 500 patients, demonstrating superiority over vehicle in reducing inflammatory lesions 1. The treatment typically involves applying a thin layer of Metrogel 1% to affected areas of the face twice daily, morning and evening, after gentle cleansing.
Some key points to consider when using Metrogel 1% for rosacea include:
- Treatment typically continues for several weeks, with most patients seeing improvement within 3-9 weeks, though it may be prescribed for longer periods to maintain results 1
- Metrogel 1% works by reducing inflammation and possibly by decreasing the population of Demodex mites that may contribute to rosacea symptoms
- It also has antimicrobial properties that help control the skin condition
- Common side effects include skin irritation, dryness, or redness
- While using Metrogel 1%, patients should avoid alcoholic beverages as they may cause a disulfiram-like reaction (nausea, vomiting, flushing) and protect their skin from sun exposure, as this medication may increase sensitivity to UV light 1
It is essential to continue using the medication as prescribed even after symptoms improve to prevent recurrence of rosacea flares. As noted in a study comparing metronidazole 0.75% and 1.0% strengths, both were equally effective when used once daily, highlighting the importance of consistent treatment 1.
From the Research
Metrogel 1% for Rosacea
- Metrogel 1% is a topical metronidazole formulation used for the treatment of rosacea 2.
- It has been shown to be effective in reducing inflammatory lesion counts and preventing relapses of the disease 2, 3.
- A study comparing once-daily metronidazole 1% gel with twice-daily azelaic acid 15% gel found similar reductions in inflammatory lesion counts and high success rates in both global severity and erythema 3.
- Metronidazole 1% gel is thought to reduce inflammation associated with rosacea by inhibiting the production of reactive oxygen species produced by neutrophils 3.
- Topical metronidazole, including Metrogel 1%, is a commonly used and established therapeutic regimen for the papulopustular subtype of rosacea with moderate to severe intensity 4.
- Combination therapy of anti-inflammatory dose doxycycline and topical metronidazole, such as Metrogel 1%, may have synergy effects 4.
- Metrogel 1% is also used in combination with oral antibiotics, such as doxycycline, for the treatment of rosacea 5, 4.
- Maintenance treatment with topical metronidazole, including Metrogel 1%, decreases relapses and allows for longer intervals between flares 5.