Can corticosteroids be used to treat cheilitis (inflammation of the lips) and angular cheilitis (inflammatory lesion at the corner of the mouth)?

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Last updated: May 15, 2025View editorial policy

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From the Guidelines

Topical steroids can be used for cracked lips and angular cheilitis, but their use should be cautious and limited due to potential side effects, as noted in guidelines from 1 and 1. When considering the use of steroids for cracked lips and angular cheilitis, it's crucial to weigh the benefits against the risks. The most recent and highest quality evidence suggests that topical corticosteroids can be effective in reducing inflammation and symptoms associated with these conditions.

  • For mild cases, low-potency steroid creams like 1% hydrocortisone can be applied thinly to affected areas 2-3 times daily for 7-10 days, as this approach minimizes the risk of side effects while still providing therapeutic benefits.
  • However, it's essential to use steroids cautiously on the face and for short durations only, as prolonged use can cause skin thinning, increased susceptibility to infections, and rebound effects when stopped, as warned by 1. Additionally, addressing underlying causes of angular cheilitis, such as fungal infections, vitamin deficiencies, or moisture issues, is crucial for effective management. If symptoms don't improve within a week of treatment or worsen, medical consultation is recommended, as other treatments may be more appropriate. The use of topical corticosteroids, as mentioned in 1, should be considered in the context of overall patient care, prioritizing morbidity, mortality, and quality of life outcomes.

From the Research

Treatment Options for Cracked Lips and Angular Cheilitis

  • Steroids can be used as a treatment option for angular cheilitis, as evidenced by the use of 0.1% diflucortolone valerate (DFV) ointment in combination with 1% isoconazole nitrate (ISN) 2
  • The anti-inflammatory properties of DFV make it a potentially effective treatment for reducing the symptoms of angular cheilitis, such as erythema and ulcerations 2
  • However, it is essential to note that the treatment of angular cheilitis should be focused on addressing the underlying etiology, which may include nutritional, systemic, or drug-related factors 3
  • Topical treatments, including steroids, should be used in conjunction with other therapies aimed at addressing the underlying causes of the condition 3
  • Further research is needed to assess the effectiveness of different treatment options, including steroids, for angular cheilitis and to determine the most appropriate treatment approaches for individual patients 2

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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