From the Guidelines
Delta 8 THC-induced hyperesthesia is not a formally recognized disease, but it represents a potential adverse effect of delta 8 THC use, as evidenced by reports of adverse events, including accidental intoxication and psychosis, associated with the use of delta 8 THC products 1.
Definition and Symptoms
Delta 8 THC, a psychoactive cannabinoid chemically similar to delta 9 THC, can cause hyperesthesia, an abnormal increase in sensitivity to sensory stimuli like touch, temperature, or pain, as noted in the context of its unregulated and unstudied health effects 1. This reaction typically manifests as uncomfortable skin sensations, heightened sensitivity to stimuli, or pain that would not normally be painful.
Management and Recommendations
If experiencing these symptoms after delta 8 THC use, discontinuation of the substance is the primary recommendation, as symptoms usually resolve within hours to days after stopping use 1. No specific medication regimen exists for this condition, though symptomatic relief might include cool compresses for skin discomfort, staying in a calm environment with reduced sensory stimulation, and adequate hydration.
Underlying Mechanism
These reactions likely occur due to delta 8 THC's interaction with the endocannabinoid system, which regulates pain perception and sensory processing, as implied by the potential health effects of delta 8 THC and other hemp-derived products 1. Individual factors such as dosage, frequency of use, and personal sensitivity to cannabinoids influence whether someone experiences this effect. Given the lack of regulation and study on delta 8 THC products, caution is advised, and users should be aware of the potential for adverse effects, including hyperesthesia.
From the Research
Delta 8 THC Induced Hyperesthesia
- There is limited research on delta-8-THC induced hyperesthesia, and no studies directly address this topic 2, 3, 4, 5, 6.
- However, studies suggest that delta-8-THC can produce physiological and toxicological effects similar to delta-9-THC, including potential adverse effects on mental health 3, 5.
- A case report describes three individuals who developed psychotic and paranoid symptoms after using delta-8-THC, highlighting the potential for adverse psychiatric effects 5.
- Another study found that delta-8-THC users reported experiencing relaxation, euphoria, and pain relief, but also cognitive distortions and difficulties with short-term memory 4.
- The lack of regulation and quality control in the production and sale of delta-8-THC products raises concerns about their safety and potential for adverse effects 3, 6.
Adverse Effects of Delta 8 THC
- Delta-8-THC has been associated with reports of medical emergencies, including calls to poison control centers and presentations to emergency departments 3.
- The substance has also been linked to psychotic symptoms, paranoia, and cognitive distortions in some users 4, 5.
- The potential for delta-8-THC to produce adverse effects, particularly in vulnerable populations such as children and adolescents, is a concern 6.
Regulation and Safety
- The legal status of delta-8-THC is unclear, and its production and sale are largely unregulated 3, 6.
- There is a need for laws and regulations to mitigate the risks associated with delta-8-THC use, including quality control of synthesis and minimum purchase age 6.
- Further research is needed to understand the prevalence and consequences of delta-8-THC use, particularly in nationally representative samples 6.