From the Guidelines
The normal estimated glomerular filtration rate (eGFR) for a 42-year-old male is approximately 120 to 130 mL/min per 1.73 m2, as stated in the national kidney foundation practice guidelines for chronic kidney disease 1.
Key Considerations
- eGFR values naturally decline with age, with a decrease of approximately 1 mL/min/1.73m² per year after age 30.
- A GFR level less than 60 mL/min per 1.73 m2 represents loss of half or more of the adult level of normal kidney function, and is associated with an increased prevalence of complications of chronic kidney disease 1.
- For men in their 40s, eGFR values between 90-120 mL/min/1.73m² are generally considered within the normal range, but the exact value can vary depending on individual factors such as muscle mass and hydration status.
Factors Affecting eGFR Measurements
- Hydration status: dehydration can lead to artificially low eGFR readings, while overhydration can lead to artificially high readings.
- Muscle mass: individuals with more muscle mass may have higher eGFR readings due to the increased creatinine production.
- Certain medications: some medications, such as those that affect kidney function or creatinine levels, can impact eGFR measurements.
Recommendations
- Regular monitoring of kidney function through eGFR testing is recommended for individuals with risk factors such as diabetes, hypertension, or family history of kidney disease.
- If a 42-year-old male has an eGFR below 90, further evaluation may be warranted, especially if there are other signs of kidney dysfunction such as proteinuria or hematuria.
From the Research
Normal eGFR Values
- The normal eGFR value for a 42-year-old male is not explicitly stated in the provided studies 2, 3, 4, 5, 6.
- However, study 5 mentions that patients with eGFR > 90 mL/min/1.73 m2 were included in the analysis, implying that an eGFR value above 90 may be considered normal.
- Study 6 also mentions that patients with stable CKD stage III/IV (estimated glomerular filtration rate [eGFR] 15-60 mL min(-1) 1.73 m(-2)) were included in the analysis, suggesting that eGFR values below 60 may indicate some level of kidney dysfunction.
Factors Affecting eGFR
- Study 4 found that the risk of ACE-I/ARB discontinuation increased with more advanced CKD stage, with patients who initiated ACE-I/ARB with CKD stage G4 (eGFR: 15-29 mL/min/1.73 m2) being 2.09-fold more likely to discontinue therapy than those with eGFR ≥ 90 mL/min/1.73 m2.
- Study 5 found that patients with eGFR < 45 mL/min/1.73 m2 had significantly lower rates of ACE-I/ARB use following hospitalization.
- Study 6 found that neither continuation of high doses of ACEI/ARB nor up-titration was related to adverse changes in longer-term renal function in patients with systolic CHF and stable CKD stage III/IV.
eGFR and ACE-I/ARB Use
- Study 2 discusses the design of a clinical trial to assess the effect of combination losartan and lisinopril on the progression of kidney disease in patients with diabetes and overt proteinuria.
- Study 3 suggests that ACE-I/ARB can slow the progression of renal insufficiency and may have a cardio-protective effect.
- Study 5 found that ACE-I/ARB use following discharge was associated with a 25% lower risk of mortality, without evidence that this association differed by eGFR.