Differential Diagnosis for Hyperbilirubinemia and Petechia
Single Most Likely Diagnosis
- Viral Hepatitis with Thrombocytopenia: This condition can cause hyperbilirubinemia due to liver inflammation and petechia due to thrombocytopenia, which is a common complication of viral hepatitis.
Other Likely Diagnoses
- Immune Thrombocytopenic Purpura (ITP) with Hemolysis: ITP can cause petechia due to low platelet count, and if there's associated hemolysis, it can lead to hyperbilirubinemia.
- Hemolytic Uremic Syndrome (HUS): HUS is characterized by hemolytic anemia, thrombocytopenia, and renal failure, which can cause hyperbilirubinemia and petechia.
- Liver Disease with Portal Hypertension: Liver diseases such as cirrhosis can cause hyperbilirubinemia and portal hypertension, leading to thrombocytopenia and petechia.
Do Not Miss Diagnoses
- Meningococcemia: This is a life-threatening condition that can cause petechia and hyperbilirubinemia due to sepsis and liver dysfunction. Early diagnosis and treatment are crucial.
- Disseminated Intravascular Coagulation (DIC): DIC can cause both thrombocytopenia and hyperbilirubinemia due to consumption of clotting factors and liver dysfunction.
- Severe Sepsis: Sepsis can cause hyperbilirubinemia and petechia due to liver dysfunction, thrombocytopenia, and coagulopathy.
Rare Diagnoses
- Hereditary Spherocytosis with Splenomegaly: This rare genetic disorder can cause hemolytic anemia, leading to hyperbilirubinemia, and splenomegaly can cause thrombocytopenia and petechia.
- Gaucher's Disease: This rare genetic disorder can cause liver dysfunction, leading to hyperbilirubinemia, and thrombocytopenia, leading to petechia.
- Lymphoma with Liver Involvement: Lymphoma can cause liver dysfunction, leading to hyperbilirubinemia, and thrombocytopenia, leading to petechia.