What is the cause of knee pain and inability to extend the knee?

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Last updated: May 16, 2025View editorial policy

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Differential Diagnosis for Knee Pain and Inability to Extend Knee

  • Single Most Likely Diagnosis
    • Patellar fracture or patellar tendinosis: The inability to extend the knee is a common presentation of patellar fractures or severe patellar tendinosis, as the patella and its tendon play a crucial role in knee extension.
  • Other Likely Diagnoses
    • Quadriceps tendon rupture: A rupture of the quadriceps tendon can lead to an inability to extend the knee, as it disrupts the continuity of the extensor mechanism.
    • Meniscal tear: A large meniscal tear, especially a bucket-handle tear, can mechanically block knee extension.
    • Ligamentous sprain (e.g., ACL, PCL): Severe ligamentous sprains can cause pain and instability, potentially limiting knee extension.
    • Osteoarthritis: Advanced osteoarthritis can cause pain and mechanical obstruction, leading to limited knee mobility, including extension.
  • Do Not Miss Diagnoses
    • Septic arthritis: Although less common, septic arthritis is a medical emergency that requires prompt diagnosis and treatment. Knee pain and limited mobility can be presenting symptoms.
    • Osteonecrosis: Avascular necrosis of the femoral condyle can cause severe knee pain and limited mobility, including an inability to extend the knee.
    • Tumor (e.g., osteosarcoma): Bone tumors can cause pain, swelling, and limited mobility. Although rare, they are critical to diagnose early.
  • Rare Diagnoses
    • Rheumatoid arthritis: Although not typically presenting with a sudden inability to extend the knee, rheumatoid arthritis can cause severe knee inflammation and limited mobility in advanced cases.
    • Hemophilia: In patients with hemophilia, a hemorrhage into the knee joint (hemarthrosis) can cause severe pain, swelling, and limited mobility.
    • Complex regional pain syndrome (CRPS): A rare condition characterized by chronic pain, inflammation, and hypersensitivity, which can affect the knee and limit its mobility.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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