From the Research
Factor V deficiency is a rare bleeding disorder that requires prompt treatment with fresh frozen plasma (FFP) to prevent life-threatening bleeding complications, with a target Factor V level of at least 25% for major bleeding or surgeries 1.
Implications of Factor V Deficiency
The implications of Factor V deficiency are significant, with patients at risk of experiencing prolonged bleeding times, easy bruising, and mucosal bleeding, which can range from mild to life-threatening 2, 3, 4.
Diagnosis and Treatment
Diagnosis is typically made using routine coagulation tests and Factor V activity assays, with genetic testing also available to identify specific mutations in the F5 gene 1.
- Treatment involves replacement therapy with FFP as needed for bleeding episodes or before surgical procedures
- Administer 15-20 mL/kg of FFP initially, then 5-10 mL/kg every 12 hours as needed
- Target Factor V levels of 15-20% for minor bleeding/procedures and >25% for major bleeding/surgeries
- Monitor Factor V levels and adjust dosing accordingly
Management and Prevention
Patients with Factor V deficiency should avoid aspirin and other blood-thinning medications, and women may benefit from hormonal contraceptives to reduce menstrual bleeding 2, 4.
- Genetic counseling is recommended for family members
- A multidisciplinary approach to management is essential, particularly in cases of severe Factor V deficiency or complex surgical procedures 5
Quality of Life and Morbidity
The quality of life for patients with Factor V deficiency can be significantly impacted by the risk of bleeding complications, highlighting the importance of prompt and effective treatment to prevent morbidity and mortality 1.
- Patients should be aware of the signs and symptoms of bleeding and seek medical attention immediately if they experience any unusual bleeding or bruising.