From the Guidelines
CRP levels in patients on CRRT can range from normal to significantly elevated, typically exceeding 100 mg/L in cases of severe inflammation or sepsis, as the CRRT process itself does not directly affect CRP levels. The level of CRP in a patient on continuous renal replacement therapy (CRRT) is primarily determined by the patient's underlying inflammatory condition rather than the CRRT process itself 1. CRP is an acute-phase protein that is synthesized in the liver in response to inflammatory insults, and its levels can double every 8 hours, peaking at 36-50 hours after the initial insult 1. Some key points to consider when interpreting CRP levels in CRRT patients include:
- CRP is not effectively removed by CRRT membranes due to its large size (115 kDa) 1
- Elevated CRP levels typically indicate ongoing inflammation from conditions such as sepsis, trauma, surgery, or the inflammatory response that may have contributed to their acute kidney injury
- Trends in CRP levels, rather than absolute values, provide more valuable information about the patient's clinical progression
- Correlating CRP levels with other clinical and laboratory parameters is essential to guide treatment decisions 1. In clinical practice, CRP levels can vary widely in patients on CRRT, and it is crucial to consider the patient's overall clinical context when interpreting these levels 1.
From the Research
CRP Levels in Patients on CRRT
- There is no direct information available on CRP levels in patients on Continuous Renal Replacement Therapy (CRRT) from the provided studies 2, 3, 4, 5, 6.
- The studies primarily focus on the pharmacokinetics of antibiotics such as meropenem and vancomycin in patients undergoing CRRT 2, 5, 6.
- One study discusses the application and considerations of CRRT in patients with acute kidney injury, severe sepsis, or septic shock, but does not mention CRP levels 3.
- Another study provides a practical update on renal replacement therapy, including CRRT, but also does not discuss CRP levels 4.
Related Information
- CRRT is often used in critically ill patients with acute kidney injury, severe sepsis, or septic shock 3, 4.
- The optimal dosing regimens for antibiotics such as meropenem and vancomycin in patients on CRRT are still being researched and may depend on various factors, including the type of CRRT and the patient's clinical condition 2, 5, 6.