From the Research
The normal level of factor XIII in neonates is typically similar to adult values, with levels ranging from 0.8-1.2 IU/mL (or 80-120 U/dL) at birth. It's essential to note that factor XIII levels in neonates remain relatively stable over the first few months of life, with minimal changes observed. For clinical purposes, a factor XIII level above 50% (0.5 IU/mL or 50 U/dL) is usually considered sufficient for normal hemostasis in neonates. If factor XIII deficiency is suspected in a neonate, specific factor XIII assays should be performed, as routine coagulation tests may not detect this deficiency 1. Understanding these normal ranges is crucial for accurately diagnosing factor XIII deficiency in newborns and distinguishing it from the physiologically lower levels expected in this age group. Key points to consider include:
- Factor XIII plays a critical role in stabilizing blood clots and preventing excessive bleeding
- Neonates with factor XIII deficiency may present with bleeding complications, such as prolonged umbilical stump bleeding or bruising
- Accurate diagnosis and management of factor XIII deficiency are essential to prevent long-term complications and improve outcomes in affected neonates 2. In the context of real-life clinical medicine, it is crucial to prioritize the diagnosis and management of factor XIII deficiency in neonates, given the potential for severe bleeding complications and long-term morbidity. Therefore, it is recommended to maintain a high index of suspicion for factor XIII deficiency in neonates presenting with bleeding complications, and to perform specific factor XIII assays to confirm the diagnosis.