From the Research
Celebrex (celecoxib) is not typically known to cause low blood sugar (hypoglycemia) as a common side effect. Celebrex is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing inflammation and pain by blocking COX-2 enzymes, but it does not directly affect blood glucose regulation mechanisms in the body. While rare cases of hypoglycemia have been reported with some NSAIDs, Celebrex is not commonly associated with this effect. However, patients who are taking medications for diabetes alongside Celebrex should be aware that NSAIDs can sometimes enhance the effect of certain diabetes medications, potentially leading to lower blood sugar levels indirectly. This interaction occurs because NSAIDs may affect kidney function, which can alter how the body processes diabetes medications 1. If you're taking Celebrex and experience symptoms of low blood sugar such as shakiness, dizziness, confusion, or unusual hunger, you should contact your healthcare provider. This is particularly important for diabetic patients or those with a history of blood sugar regulation issues. Some studies have shown that celecoxib may have a protective effect on diabetic neuropathy by decreasing apoptosis and oxidative stress in dorsal root ganglion neurons via the miR-155/COX-2 axis 2. Additionally, celecoxib has been found to exhibit potential antidepressant-like effects in depression associated with obesity, which may be mediated by reversing altered plasma glucose levels in obese mice 3. However, these findings do not directly relate to the risk of hypoglycemia associated with Celebrex. It's essential to note that the provided studies 4, 5 do not directly address the question of Celebrex causing low blood sugar, but they do provide information on the effects of other medications and conditions on blood glucose regulation. In summary, Celebrex is not typically associated with causing low blood sugar, but patients taking diabetes medications should be aware of the potential indirect effects of NSAIDs on blood sugar levels.