From the Research
Estrogen patches should be applied to clean, dry, hairless areas of the lower abdomen, buttocks, or upper outer thigh, as these sites provide consistent absorption of the hormone through the skin and into the bloodstream, bypassing the liver and allowing for steady hormone levels compared to oral estrogen. When applying an estrogen patch, it is essential to avoid placing it on the breasts, waistline, or any areas where tight clothing might rub against it. Each new patch should be applied to a different location than the previous one to prevent skin irritation. Before application, ensure the skin is free of lotions, oils, or powders that could prevent proper adhesion. The patch should be firmly pressed for about 10 seconds to ensure good contact with the skin. Follow the specific replacement schedule prescribed by your healthcare provider, which is typically twice weekly (every 3-4 days) for most estrogen patches. If a patch falls off, apply a new one immediately. According to a study published in the International journal of clinical pharmacology and therapeutics 1, the relative bioavailability of transdermally administered estrogen was equal when the patch was applied to the buttocks or abdomen, and patch adhesion and tolerability were good, with no relevant differences between sites. However, it is crucial to prioritize the most recent and highest quality study, and in this case, the study from 2014 1 provides the most relevant information for determining the recommended application sites for estrogen patches. Some other studies, such as those published in Menopause (New York, N.Y.) 2, 3, and Clinical pharmacology and therapeutics 4, provide additional information on the effects of estrogen therapy, but they do not directly address the recommended application sites for estrogen patches. Therefore, based on the available evidence, the recommended areas of the body to apply an estrogen patch are the lower abdomen, buttocks, or upper outer thigh.